Structural formula of Toluene-2,5-diamine


What is it?

Toluene-2,5-diamine (chemical formula C7H10N2), also called toluene-2,5-diamine sulfate (C7H10N2.H2O4S), is in the physical form ‘light yellow to light pink’ or ‘grey to white powder’.

What are the effects?

This substance belongs to the groups:

Toluene-2,5-diamine and its salts are restricted for use in cosmetics in the European Union by CosIng. CosIng is the European Commission database for information on cosmetic substances and ingredients.

The EU Scientific Committee on Consumer Safety (SCCS) has the opinion that “toluene-2,5-diamine and its sulphate salt cannot be considered safe for use as an oxidative hair dye with a concentration on-head of maximum 4.0%”

The European Comissins Scientific Committee on Consumer Products (SCCP) writes that “the SCCP is of the opinion that the use of toluene-2,5-diamine cannot be considered safe based on the available data” and “Toluene-2,5-diamine is an extremely potent skin sensitiser.”

This substances contains amines and can form toxic nitrosamines in products.


Even though it is not listed on the list of ingredients, products with toluene-2,5-diamine may contain impurities from:

  • Nitrosamines –  Linked to endocrine disruption, cancer, organ system toxicity, and is prohibited to use in cosmetics in the EU and Canada.

How is it used?

In cosmetics*, toluene-2,5-diamine is used as a hair dye substance in oxidative hair dye products.

We use the European Commissions definition of Cosmetics:
“Cosmetics range from everyday hygiene products such as soap, shampoo, deodorant, and toothpaste to luxury beauty items including perfumes and makeup”.

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